{"created":"2024-05-22T03:56:20.209046+00:00","id":2000016,"links":{},"metadata":{"_buckets":{"deposit":"fa5bcb87-a893-42db-becf-5bb338635916"},"_deposit":{"created_by":19,"id":"2000016","owner":"19","owners":[19],"pid":{"revision_id":0,"type":"depid","value":"2000016"},"status":"published"},"_oai":{"id":"oai:kyujyo.repo.nii.ac.jp:02000016","sets":["1:4:1716269449145"]},"author_link":[],"control_number":"2000016","item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-09-30","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"35","bibliographicPageStart":"25","bibliographicVolumeNumber":"60","bibliographic_titles":[{"bibliographic_title":"九州女子大学紀要","bibliographic_titleLang":"ja"},{"bibliographic_title":"Bulletin of Kyushu Women's University","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ミクログリアは感染症や脳損傷時に炎症を誘発したり抑制する事で脳内の恒常性を維持している。\nWnt5Aでミクログリアを刺激すると炎症誘発・炎症応答遺伝子の発現や細胞遊走を促進する事からWnt5A\nを発現しているアストロサイト―ミクログリア間の作用によりこれらが制御されている可能性が報告されて\nいる。LRP4は運動神経終末から分泌されるアグリンの受容体でシナプス後部のアセチルコリン受容体の集\n積化を促進する事で神経・筋接合部の形成維持に働くがWntsの受容体としても働きWntシグナルの抑制や\nWntsによるアセチルコリン受容体の集積化も報告されている。\n　本研究ではLRP4を欠失したマウス由来の初代培養ミクログリアを用いWnt3A、Wnt5Aによる細胞増殖、\nNO産生と細胞遊走能を同腹の野生型ミクログリアと比較した。これらWntsの添加により炎症誘発・炎症応\n答遺伝子の発現、細胞増殖、NO産生や細胞遊走能の増加が見られたがLRP4の有無による有意な差は見ら\nれずLRP4はWnt3A、Wnt5Aによるミクログリアの炎症応答には関与していないと考えられる。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"Microglia maintain brain homeostasis by inducing and suppressing inflammation during infection and\nbrain injury. LRP4 is a receptor for agrin, which is secreted from motor nerve endings and promotes the\naccumulation of acetylcholine receptors in the postsynaptic region, thereby maintaining the formation of\nneuromuscular junctions. receptor accumulation by Wnts has also been reported.\nIn this study, I compared the cell proliferation, NO production, and migration ability of Wnt3A and Wnt5A\nin primary cultured microglia derived from mice lacking LRP4 with those of wild-type microglia from the same\nstomach. The addition of these Wnts increased the expression of inflammation-inducing and inflammationresponsive\ngenes, cell proliferation, NO production, and cell migration ability, but there was no significant\ndifference between the presence and absence of LRP4, suggesting that LRP4 is not involved in the\ninflammatory response of microglia induced by Wnt3A and Wnt5A.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10002_full_name_3":{"attribute_name":"著者（英）","attribute_value_mlt":[{"names":[{"name":"Hiroshi TANAHASHI","nameLang":"en"}]}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"九州女子大学","subitem_publisher_language":"ja"}]},"item_10002_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12452639","subitem_source_identifier_type":"NCID"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1884-0159","subitem_source_identifier_type":"PISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"棚橋浩","creatorNameLang":"ja"},{"creatorName":"タナハシヒロシ","creatorNameLang":"ja-Kana"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-05-22"}],"filename":"kiyo60-1-3.pdf","filesize":[{"value":"2.7 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"url":"https://kyujyo.repo.nii.ac.jp/record/2000016/files/kiyo60-1-3.pdf"},"version_id":"2087a081-6271-44e3-b88f-e33d38eaa6ca"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"LRP4","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"microglia","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"migration","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"NO","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Wnt","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ミクログリアに対して炎症誘導作用を持つWnt3A、 Wnt5Aシグナル経路の炎症誘導により起こる細胞増殖、細胞遊走や NO産生に及ぼすLDL receptor related protein 4 (LRP4) の影響","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ミクログリアに対して炎症誘導作用を持つWnt3A、 Wnt5Aシグナル経路の炎症誘導により起こる細胞増殖、細胞遊走や NO産生に及ぼすLDL receptor related protein 4 (LRP4) の影響","subitem_title_language":"ja"},{"subitem_title":"Effects of LDL receptor-related protein 4 (LRP4) on cell proliferation, cell migration and NO production induced by inflammation of Wnt3A and Wnt5A signaling pathways that have inflammation-inducing effects on microglia","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"19","path":["1716269449145"],"pubdate":{"attribute_name":"公開日","attribute_value":"2024-05-22"},"publish_date":"2024-05-22","publish_status":"0","recid":"2000016","relation_version_is_last":true,"title":["ミクログリアに対して炎症誘導作用を持つWnt3A、 Wnt5Aシグナル経路の炎症誘導により起こる細胞増殖、細胞遊走や NO産生に及ぼすLDL receptor related protein 4 (LRP4) の影響"],"weko_creator_id":"19","weko_shared_id":-1},"updated":"2024-07-19T06:46:26.109819+00:00"}